Felbamate-d4

Felbamate-d4 (W-554-d4) is the deuterium labeled Felbamate. Felbamate (W-554) is a potent anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .

Product Specifications

CAS Number

[106817-52-1]

UNSPSC

12352005

Hazard Statement

H336-H372

Target

IGluR

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.00

Solubility

10 mM in DMSO|DMF : ≥ 50mg/mL|DMSO : ≥ 30mg/mL|Ethanol : ≥ 1mg/mL

Smiles

C(C(OC(N)=O)([2H])[2H])(C(OC(N)=O)([2H])[2H])C1=CC=CC=C1

Molecular Formula

C11H10D4N2O4

Molecular Weight

242.26

Precautions

P260-P261-P264-P270-P271-P304+P340-P403+P233-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kuo CC, et al. Use-dependent inhibition of the N-methyl-D-aspartate currents by felbamate: a gating modifier with selective binding to the desensitized channels. Mol Pharmacol. 2004 Feb;65 (2) :370-80.|[3]Harty TP, et al. Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000 Mar;39 (1) :47-55.