Guanidine-d5 (hydrochloride)

Guanidine-d5 (hydrochloride) is the deuterium labeled Guanidine hydrochloride[1]. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[2][3].

Product Specifications

CAS Number

[108694-93-5]

Product Name Alternative

Guanidinium-d5 (chloride) ; Aminoformamidine-d5 (hydrochloride)

UNSPSC

12352211

Hazard Statement

H302, H315, H319

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

Solubility

10 mM in DMSO

Smiles

[2H]/N=C(N([2H])[2H])/N([2H])[2H].Cl[2H]

Molecular Formula

CD6ClN3

Molecular Weight

101.57

Precautions

H302, H315, H319

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231 (2) :180-4.|[3]G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul43 (1) :7-10.|[4]Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8450 (4) :1339-44.|[5]E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec2 (6) :339-46.