Prilocaine-d7 (hydrochloride)

Prilocaine-d7 (hydrochloride) is deuterium labeled Prilocaine (hydrochloride) . Prilocaine hydrochloride, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects[1][2].

Product Specifications

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Na+/K+ ATPase

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

98.16

Solubility

10 mM in DMSO

Smiles

CC(NCCC)C(NC1=C(C([2H])([2H])[2H])C([2H])=C([2H])C([2H])=C1[2H])=O.Cl

Molecular Formula

C13H14D7ClN2O

Molecular Weight

263.81

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]H Kutchai, et al. Effects of local anaesthetics on the activity of the Na, K-ATPase of canine renal medulla. Pharmacol Res. 2000 Jan;41 (1) :1-7.|[3]M Mete, et al. Neurotoxic effects of local anesthetics on the mouse neuroblastoma NB2a cell line. Biotech Histochem. 2015 Apr;90 (3) :216-22.