Bestatin-d7 (hydrochloride)

Bestatin-d7 (hydrochloride) is deuterium labeled Bestatin (hydrochloride) . Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N) /APN and leukotriene A4 hydrolase, used for cancer research.

Product Specifications

Product Name Alternative

Ubenimex-d7 (hydrochloride)

UNSPSC

12352005

Target

Aminopeptidase; Antibiotic; Bacterial; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Purity

97.73

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@H](CC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O.Cl

Molecular Formula

C16H18D7ClN2O4

Molecular Weight

351.88

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hossain A, et al. Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice. Exp Eye Res. 2016 Aug;149:100-6|[3]Lis M, et al. The effects of bestatin on humoral response to sheep erythrocytes in non-treated and cyclophosphamide-immunocompromised mice. Immunopharmacol Immunotoxicol. 2013 Feb;35 (1) :133-8|[4]Poloz Y, et al. Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum. Eukaryot Cell. 2012 Apr;11 (4) :545-57|[5]Qian X, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2016 May-Jun;23 (3) :e680-9.