Norfloxacin (nicotinate)

Norfloxacin nicotinate (MK-0366 nicotinate) is a fluoroquinolones antibiotic, an adduct of Norfloxacin (NOR) and nicotinic acid. Norfloxacin nicotinate has been widely used for replacing NOR in animal husbandry and fishery industry. Norfloxacin nicotinate can induce innate immune response at a high concentration[1].

Product Specifications

CAS Number

[118803-81-9]

Product Name Alternative

MK-0366 (nicotinate)

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/norfloxacin-nicotinate.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C1=O)O.O=C(C4=CC=CN=C4)O

Molecular Formula

C22H23FN4O5

Molecular Weight

442.44

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Liang X, et al. Effects of norfloxacin nicotinate on the early life stage of zebrafish (Danio rerio) : Developmental toxicity, oxidative stress and immunotoxicity. Fish Shellfish Immunol. 2020 Jan;96:262-269.