PF-06462894
PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator profiled in both rat and nonhuman primates[1].
Product Specifications
CAS Number
1622291-66-0
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-06462894.html
Smiles
O=C1C=C(OCC2=CC=CC=N2)N=C3N1[C@H](CC(C)(C)C)COC3
Molecular Formula
C18H23N3O3
Molecular Weight
329.39
References & Citations
[1]Antonia F. Stepan, et al. Discovery and Characterization of (R) -6-Neopentyl-2- (pyridin-2-ylmethoxy) -6,7-dihydropyrimido[2,1-c][1,4]oxazin-4 (9H) -one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. J. Med. Chem. 2017, 60, 18, 7764–7780
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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