Tigecycline (hydrate)

Tigecycline (GAR-936) hydrate is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline hydrate for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively[2].

Product Specifications

CAS Number

[1229002-07-6]

Product Name Alternative

GAR-936 (hydrate)

UNSPSC

12352005

Hazard Statement

H317, H318, H360, H410

Target

Antibiotic; Autophagy; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/tigecycline-hydrate.html

Purity

99.51

Solubility

10 mM in DMSO

Smiles

O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])CC4=C(C(C3=C(O)[C@@]21O)=O)C(O)=C(NC(CNC(C)(C)C)=O)C=C4N(C)C)N.O.[x]

Molecular Formula

C29H39N5O8.xH2O

Precautions

H317, H318, H360, H410

References & Citations

[1]Jitkova Y, et al. A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity. PLoS One. 2014 May 28;9 (5) :e95281.|[2]Falagas ME, et al. Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals. Int J Antimicrob Agents. 2018 Aug;52 (2) :269-271.