What is the catalog number for Ketoconazole-d4?

The catalog number for Ketoconazole-d4 is HY-B0105S1.

What sizes are available for Ketoconazole-d4?

Ketoconazole-d4 is available in the following size(s): 1 mg.

Is Ketoconazole-d4 in stock?

Ketoconazole-d4 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Ketoconazole-d4?

Ketoconazole-d4 is manufactured by QuantiMol.

What is the estimated delivery time for Ketoconazole-d4?

Estimated delivery time for Ketoconazole-d4 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Ketoconazole-d4?

The safety data sheet for Ketoconazole-d4 is available here: http://file.medchemexpress.com/batch_PDF/HY-B0105S1/Ketoconazole-d4-SDS-MedChemExpress.pdf.

Ketoconazole-d4

Ketoconazole-d4 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

Product Specifications

CAS Number

1398065-75-2

Product Name Alternative

Ketoconazol-d4; R 41400-d4

UNSPSC

12352005

Target

Cytochrome P450; Fungal; Ras

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Field of Research

Infection; Cancer

Purity

99.63

Solubility

10 mM in DMSO|DMSO : 25mg/mL (ultrasonic)

Smiles

CC(N(CC1([2H])[2H])CC([2H])([2H])N1C(C=C2)=CC=C2OC[C@@H](CO3)O[C@]3(C4=C(C=C(C=C4)Cl)Cl)CN5C=CN=C5)=O

Molecular Formula

C26H24D4Cl2N4O4

Molecular Weight

535.46

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51 (2) :165-75.|[3]Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24 (8) :367-70.|[4]Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151 (9) :4301-12.|[5]Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8 (1) :8161.