Ketoconazole-d8
Ketoconazole-d8 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
Product Specifications
CAS Number
1217706-96-1
UNSPSC
12352005
Hazard Statement
H301, H360, H373, H410
Target
Cytochrome P450; Fungal; Isotope-Labeled Compounds; Ras
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others
Field of Research
Infection; Cancer
Purity
99.79
Solubility
10 mM in DMSO
Smiles
CC(N(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])N1C(C=C2)=CC=C2OC[C@@H](CO3)O[C@]3(C4=C(C=C(C=C4)Cl)Cl)CN5C=CN=C5)=O
Molecular Formula
C26H20D8Cl2N4O4
Molecular Weight
539.48
Precautions
H301, H360, H373, H410
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51 (2) :165-75.|[3]Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24 (8) :367-70.|[4]Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151 (9) :4301-12.|[5]Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8 (1) :8161.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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