Sugammadex

Sugammadex is a synthetic γ-cyclodextrin derivative, and acts as a reversal agent for neuromuscular block. Sugammadex shows nephroprotective effect in ischemia-reperfusion injury[1][2].

Product Specifications

CAS Number

[343306-71-8]

Product Name Alternative

Org25969 (free acid)

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/sugammadex.html

Solubility

H2O

Smiles

OC(CCSC[C@@H]1OC(O[C@@H]2[C@H]([C@H](O)C(O[C@H]3[C@H](CSCCC(O)=O)OC(O[C@H]4[C@H](CSCCC(O)=O)OC5[C@@H](O)[C@@H]4O)[C@@H](O)[C@@H]3O)O[C@H]2CSCCC(O)=O)O)[C@@H](O)[C@H](O)[C@H]1OC(O[C@@H](CSCCC(O)=O)[C@H](OC6[C@@H](O)[C@H](O)[C@@H](OC7[C@@H](O)[C@H](O)[C@@H](OC8[C@@H](O)[C@H](O)[C@@H](O5)[C@H](CSCCC(O)=O)O8)[C@H](CSCCC(O)=O)O7)[C@H](CSCCC(O)=O)O6)[C@H]9O)[C@H]9O)=O

Molecular Formula

C72H112O48S8

Molecular Weight

2002.15

Precautions

P264-P280-P302+P352-P362+P364

References & Citations

[1]de Boer HD, et al. Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br J Anaesth. 2006 Apr;96 (4) :473-9. Epub 2006 Feb 7.|[2]Tercan M, Yılmaz İnal F, Seneldir H, Kocoglu H. Nephroprotective Efficacy of Sugammadex in Ischemia-Reperfusion Injury: An Experimental Study in a Rat Model. Cureus. 2021 Jun 17;13 (6) :e15726.