Amrubicin
Amrubicin (SM-5887) is a DNA topoisomerase II inhibitor, used for the research of cancer.
Product Specifications
CAS Number
110267-81-7
Product Name Alternative
SM-5887
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amrubicin.html
Purity
98.0
Solubility
DMSO : ≥ 30 mg/mL
Smiles
CC([C@@](C1)(N)C[C@H](O[C@@H]2OC[C@@H](O)[C@@H](O)C2)C(C1=C3O)=C(O)C4=C3C(C5=CC=CC=C5C4=O)=O)=O
Molecular Formula
C25H25NO9
Molecular Weight
483.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Hayashi S, et al. Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction. Int J Mol Med. 2006 Nov;18 (5) :909-15.|[2]Hanada M, et al. Amrubicin, a novel 9-aminoanthracycline, enhances the antitumor activity of chemotherapeutic agents against human cancer cells in vitro and in vivo. Cancer Sci. 2007 Mar;98 (3) :447-54.|[3]Hanada M, et al. Amrubicin induces apoptosis in human tumor cells mediated by the activation of caspase-3/7 preceding a loss of mitochondrial membrane potential. Cancer Sci. 2006 Dec;97 (12) :1396-403. Epub 2006 Sep 21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Topo II
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