Donepezil-d5 (hydrochloride)

Donepezil-d5 (hydrochloride) is deuterium labeled Donepezil (Hydrochloride) . Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2].

Product Specifications

CAS Number

[1883548-90-0]

Product Name Alternative

E2020-d5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE)

Type

Isotope-Labeled Compounds

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.27

Solubility

10 mM in DMSO

Smiles

O=C1C(CC2=CC(OC)=C(C=C21)OC)CC3CCN(CC3)CC4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H].Cl

Molecular Formula

C24H25D5ClNO3

Molecular Weight

420.98

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chang Yell Shin, et al. The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents. Biomol Ther (Seoul) . 2018 May 1;26 (3) :274-281.|[3]H Ogura, et al. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22 (8) :609-13.|[4]Min-Young Noh, et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108 (5) :1116-25.