Tropisetron (Hydrochloride) (Standard)

Tropisetron (Hydrochloride) (Standard) is the analytical standard of Tropisetron (Hydrochloride) . Tropisetron Hydrochloride (SDZ-ICS-930) is an effective neuroprotective agent that acts as a 5-HT3 receptor antagonist, a calmodulin inhibitor, and an α7-nAChRreceptor agonist, with an IC50 of 70.1 nM for the 5-HT3 receptor. Tropisetron Hydrochloride has anti-inflammatory properties and immune-regulating functions, effectively alleviating symptoms associated with chemotherapy and post-surgery. Tropisetron Hydrochloride reduces Ab (HY-P4867) -induced hippocampal neuroinflammation[1][2][3][4].

Product Specifications

CAS Number

[105826-92-4]

Product Name Alternative

SDZ-ICS-930 (Standard)

UNSPSC

12352005

Target

5-HT Receptor; nAChR; Reference Standards

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/tropisetron-hydrochloride-standard.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CNC2=C1C=CC=C2)O[C@H]3C[C@H]4CC[C@H](N4C)C3.[H]Cl

Molecular Formula

C17H21ClN2O2

Molecular Weight

320.81

References & Citations

[1]Rahimian R, et al. Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats. Eur J Clin Invest. 2013 Oct;43 (10) :1039-51.|[2]Swartz MM, et al. Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action. Neuropharmacology. 2013 Oct;73:111-21.|[3]Aminian A, et al. Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis. Neuroscience. 2013 Jun 15;248C:299-306.|[4]Rahimian R, et al. Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: possible involvement of calcineurin. Brain Res. 2011 Oct 12;1417:1-8.