Pentagastrin (meglumine)

Pentagastrin (ICI-50123) meglumine is a potent, selective Cholecystokinin B (CCKB) receptor antagonists with IC50 values of 11 nM and 1100 nM for CCKB and CCKA, respectively. Pentagastrin meglumine enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury[1].[2].

Product Specifications

CAS Number

[57448-84-7]

Product Name Alternative

ICI-50123 (meglumine)

UNSPSC

12352005

Target

Cholecystokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/pentagastrin-meglumine.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CCNC(OC(C)(C)C)=O)=O)CC2=CNC3=C2C=CC=C3.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC

Molecular Formula

C44H66N8O14S

Molecular Weight

963.11

References & Citations

[1]Smith AJ, et al. Characterisation of CCKB receptors on GH3 pituitary cells: receptor activation is linked to Ca2+ mobilisation. Eur J Pharmacol. 1994 Apr 15;267 (2) :215-23.|[2]Tanaka S, et al. Pentagastrin gastroprotection against acid is related to H2 receptor activation but not acid secretion. Gut. 1998 Sep;43 (3) :334-41.