Zuclopenthixol-d4 (succinate salt)
Product Specifications
UNSPSC Description
Zuclopenthixol-d4 (succinate) is the deuterium labeled Zuclopenthixol. Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist[1][2].
Target Antigen
Dopamine Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.0
Solubility
10 mM in DMSO
Smiles
C(CC(O)=O)C(O)=O.C(CCN1CCN(C(C(O)([2H])[2H])([2H])[2H])CC1)=C2C=3C(SC=4C2=CC=CC4)=CC=C(Cl)C3
Molecular Weight
523.08
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Manzaneque JM, et al. An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice. Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21(1):11-5.|[3]Khalifa AE, et al. Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. Hum Exp Toxicol. 2004 Aug;23(9):439-45.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Clinical Information
No Development Reported
CAS Number
1246833-97-5
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