Zuclopenthixol-d4 (succinate salt)

Zuclopenthixol-d4 succinate is the deuterium labeled Zuclopenthixol. Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist[1][2].

Product Specifications

CAS Number

[1246833-97-5]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.0

Solubility

10 mM in DMSO

Smiles

C(CC(O)=O)C(O)=O.C(CCN1CCN(C(C(O)([2H])[2H])([2H])[2H])CC1)=C2C=3C(SC=4C2=CC=CC4)=CC=C(Cl)C3

Molecular Formula

C26H27D4ClN2O5S

Molecular Weight

523.08

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Manzaneque JM, et al. An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice. Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21 (1) :11-5.|[3]Khalifa AE, et al. Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. Hum Exp Toxicol. 2004 Aug;23 (9) :439-45.