Zuclopenthixol (dihydrochloride)

Zuclopenthixol ((Z) -Clopenthixol) dihydrochloride is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Zuclopenthixol dihydrochloride is used in the study of schizophrenia[1][2][3].

Product Specifications

CAS Number

[58045-23-1]

Product Name Alternative

(Z) -Clopenthixol (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zuclopenthixol-dihydrochloride.html

Purity

99.98

Solubility

10 mM in DMSO

Smiles

ClC1=CC2=C(C=C1)SC3=C(C=CC=C3)/C2=C/CCN4CCN(CC4)CCO.[H]Cl.[H]Cl

Molecular Formula

C22H27Cl3N2OS

Molecular Weight

473.89

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Khalifa AE, et al. Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. Hum Exp Toxicol. 2004 Aug;23 (9) :439-45. |[2]Manzaneque JM, et al. An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice. Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21 (1) :11-5. |[3]Bryan EJ, et al. Zuclopenthixol dihydrochloride for schizophrenia. Cochrane Database Syst Rev. 2017 Nov 16;11 (11) :CD005474.