Dapiprazole

Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis[1][2][3].

Product Specifications

CAS Number

[72822-12-9]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/dapiprazole.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=CC=C1N2CCN(CCC3=NN=C4CCCCN43)CC2

Molecular Formula

C19H27N5

Molecular Weight

325.45

References & Citations

[1]Valeri P, et al. Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice. Drug Alcohol Depend. 1989 Jan;23 (1) :73-7.|[2]Allinson RW, et al. Reversal of mydriasis by dapiprazole. Ann Ophthalmol. 1990 Apr;22 (4) :131-3, 138.|[3]Hou RH, et al. Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology (Berl) . 2007 Nov;195 (1) :41-59.