Buclizine
Buclizine is an orally active antihistamine antiallergic compound. Buclizine is a potent teratogen in the rat and shows anti-tumor activity[1][2][3].
Product Specifications
CAS Number
82-95-1
UNSPSC
12352005
Hazard Statement
H302
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/buclizine.html
Solubility
10 mM in DMSO
Smiles
CC(C1=CC=C(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)C=C1)(C)C
Molecular Formula
C28H33ClN2
Molecular Weight
433.03
Precautions
P264-P270-P330-P501
References & Citations
[1]Gamal A E Mostafa, et al. Buclizine. Profiles Drug Subst Excip Relat Methodol. 2011;36:1-33.|[2]Ean-Jeong Seo, et al. Interaction of antihistaminic drugs with human translationally controlled tumor protein (TCTP) as novel approach for differentiation therapy. Oncotarget. 2016 Mar 29;7 (13) :16818-39.|[3]C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1;95 (1) :109-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
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