Temocaprilat

Temocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE) . Temocaprilat alleviates the inhibitory effect of high glucose on the proliferation of aortic endothelial cells. Temocaprilat has potential applications in hypertension and vascular inflammation[1][2][3][4].

Product Specifications

CAS Number

[110221-53-9]

Product Name Alternative

Temocapril diacid; Temocaprilate; RS 5139

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Angiotensin-converting Enzyme (ACE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/temocaprilat.html

Solubility

10 mM in DMSO

Smiles

OC(CN1C[C@@H](C2=CC=CS2)SC[C@@H](C1=O)N[C@H](C(O)=O)CCC3=CC=CC=C3)=O

Molecular Formula

C21H24N2O5S2

Molecular Weight

448.56

Precautions

H317, H319

References & Citations

[1]Yasunari K, et al. Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation. J Cardiovasc Pharmacol. 2003 Dec;42 Suppl 1:S55-60. |[2]Püchler K, et al. Single dose and steady state pharmacokinetics of temocapril and temocaprilat in young and elderly hypertensive patients. Br J Clin Pharmacol. 1998 Oct;46 (4) :363-7. |[3]Ito N, et al. Renin-angiotensin inhibition reverses advanced cardiac remodeling in aging spontaneously hypertensive rats. Am J Hypertens. 2007 Jul;20 (7) :792-9.|[4]Yang Z H, et al. P-540: Olmesartan and temocaprilat suppress IL-1 [beta]-induced IL-6 expression via a decrease in mRNA stability in vascular smooth muscle cells[J]. American Journal of Hypertension, 2002, 15 (S3) : 228A.