Mexiletine (hydrochloride) (Standard)

Mexiletine (hydrochloride) (Standard) is the analytical standard of Mexiletine (hydrochloride) . This product is intended for research and analytical applications. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research[1][2][3][4][5].

Product Specifications

CAS Number

[5370-01-4]

Product Name Alternative

KOE-1173 (hydrochloride) (Standard)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335-H412

Target

Reference Standards; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/mexiletine-hydrochloride-standard.html

Solubility

10 mM in DMSO

Smiles

CC(N)COC1=C(C)C=CC=C1C.[H]Cl

Molecular Formula

C11H18ClNO

Molecular Weight

215.72

Precautions

P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Campbell RW, et al. Mexiletine. N Engl J Med. 1987, 316 (1) :29-34.|[2]De Bellis M, et al. Combined modifications of mexiletine pharmacophores for new lead blockers of Na (v) 1.4 channels. Biophys J. 2013, 104 (2) :344-54.|[3] Nasilli G, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010;112 (4) :473-6.|[4]Egashira N, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010, 112 (4) :473-6.