Liothyronine (sodium hydrate)

Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

Product Specifications

CAS Number

[345957-19-9]

Product Name Alternative

Triiodothyronine (sodium hydrate) ; 3,3',5-Triiodo-L-thyronine (sodium hydrate) ; T3 (sodium hydrate)

UNSPSC

12352005

Target

Endogenous Metabolite; Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/liothyronine-sodium-hydrate.html

Purity

99.28

Solubility

1 M NaOH : ≥ 100 mg/mL|H2O : 43.48 mg/mL (adjust pH to 11 with 1 M NaOH)

Smiles

N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C(I)=C2)C(O[Na])=O.[x].O

Molecular Formula

C15H12I3NO4.xH2O.Na

References & Citations

[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85 (2) :189-94.|[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195 (1) :385-92.|[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20 (11) :3622-34.