Liothyronine-13C6-1

Liothyronine-13C6-1 is a 13C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2].

Product Specifications

CAS Number

[1213431-76-5]

Product Name Alternative

Triiodothyronine-13C6-1; 3,3',5-Triiodo-L-thyronine-13C6-1; T3-13C6-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Thyroid Hormone Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/liothyronine-13c6-1.html

Concentration

152.22 μM * 1 mL in 0.1 N NH3 in Methanol

Purity

98.06

Solubility

10 mM in DMSO

Smiles

I[13C]([13CH]=[13C]([13CH]=[13C]1I)C[C@H](N)C(O)=O)=[13C]1OC2=CC(I)=C(C=C2)O

Molecular Formula

C9 13C6H12I3NO4

Molecular Weight

656.93

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85 (2) :189-94.