Eletriptan

Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[1].

Product Specifications

CAS Number

[143322-58-1]

Product Name Alternative

UK-116044

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/eletriptan.html

Solubility

10 mM in DMSO

Smiles

CN1[C@@H](CC2=CNC3=CC=C(CCS(C4=CC=CC=C4)(=O)=O)C=C32)CCC1

Molecular Formula

C22H26N2O2S

Molecular Weight

382.52

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]McCormack PL, Keating GM. Eletriptan: a review of its use in the acute treatment of migraine. Drugs. 2006;66 (8) :1129-49.|[2]Willems E, et al. Porcine carotid vascular effects of eletriptan (UK-116,044) : a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug;358 (2) :212-9.