12-epi-Tadalafil
12-epi-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM) . 12-epi-Tadalafil can be used for research of cardiovascular diseases[1].
Product Specifications
CAS Number
171596-27-3
Product Name Alternative
12-epi-IC-351
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/12-epi-tadalafil.html
Solubility
10 mM in DMSO
Smiles
O=C([C@]1([H])CC2=C([C@@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O
Molecular Formula
C22H19N3O4
Molecular Weight
389.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J Med Chem. 2003 Oct 9;46 (21) :4533-42.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE5
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