(E/Z) -THZ1 (dihydrochloride)

(E/Z) -THZ1 dihydrochloride is a selective inhibitor of CDK7 with an IC50 of 3.2 nM. (E/Z) -THZ1 dihydrochloride has antiproliferative effect[1][2].

Product Specifications

CAS Number

[2095433-94-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e-z-thz1-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5.[H]Cl.[H]Cl

Molecular Formula

C31H30Cl3N7O2

Molecular Weight

638.97

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014;511 (7511) :616-620.|[2]Nilson KA, et al. THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. Mol Cell. 2015;59 (4) :576-587.