Succinic anhydride-13C2

Succinic anhydride-13C2 is the 13C labeled Succinic anhydride[1]. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide[2].

Product Specifications

CAS Number

[67519-25-9]

UNSPSC

12352005

Hazard Statement

H302-H314-H317-H334

Target

ADC Linker

Type

Isotope-Labeled Compounds

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/succinic-anhydride-13c2.html

Solubility

10 mM in DMSO

Smiles

O=[13C]1O[13C](CC1)=O

Molecular Formula

C2 13C2H4O3

Molecular Weight

102.06

Precautions

P260-P261-P264-P270-P272-P280-P284-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P362+P364-P363-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.