Fmoc-Hyp (Bom) -OH

Fmoc-Hyp (Bom) -OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fmoc-Hyp (Bom) -OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

Product Specifications

CAS Number

[187223-15-0]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fmoc-hyp-bom-oh.html

Purity

99.85

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@@H]1C[C@@H](OC(NCCNC(OC(C)(C)C)=O)=O)CN1C(OCC2C3=C(C=CC=C3)C4=C2C=CC=C4)=O

Molecular Formula

C28H33N3O8

Molecular Weight

539.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.