(2S,3R) -Dap-NE (hydrochloride)
(2S,3R) -Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10. Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].
Product Specifications
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Microtubule/Tubulin; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2s-3r-dap-ne-hydrochloride.html
Purity
99.31
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)[C@@H](C)[C@@H](OC)[C@H]2NCCC2.Cl[H]
Molecular Formula
C18H29ClN2O3
Molecular Weight
356.89
Precautions
H302, H315, H319, H335
References & Citations
[1]Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44 (5) : 937-940.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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