(2S,3R) -Dap-NE (hydrochloride)

(2S,3R) -Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580) . Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin; Mitosis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2s-3r-dap-ne-hydrochloride.html

Purity

99.31

Solubility

10 mM in DMSO

Smiles

O=C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)[C@@H](C)[C@@H](OC)[C@H]2NCCC2.Cl[H]

Molecular Formula

C18H29ClN2O3

Molecular Weight

356.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44 (5) : 937-940.