Ethyl 4-chloro-2- (methylthio) pyrimidine-5-carboxylate

Ethyl 4-chloro-2- (methylthio) pyrimidine-5-carboxylate is a drug intermediate. Ethyl 4-chloro-2- (methylthio) pyrimidine-5-carboxylate can be used to synthesize inhibitors of various kinases such as Cdk4, PDGF, FGF, EGF[1][2].

Product Specifications

CAS Number

[5909-24-0]

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

Biochemical Assay Reagents; Drug Intermediate

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ethyl-4-chloro-2-methylthio-pyrimidine-5-carboxylate.html

Purity

99.85

Solubility

10 mM in DMSO

Smiles

O=C(OCC)C1=CN=C(SC)N=C1Cl

Molecular Formula

C8H9ClN2O2S

Molecular Weight

232.69

Precautions

H315, H319, H335

References & Citations

[1]Barvian M, et al. Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43 (24) :4606-16.|[2]Klutchko SR, et al. 2-Substituted aminopyrido[2,3-d]pyrimidin-7 (8H) -ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity. J Med Chem. 1998 Aug 13;41 (17) :3276-92.