Voriconazole (camphorsulfonate)

Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].

Product Specifications

CAS Number

[137234-71-0]

Product Name Alternative

UK-109496 (camphorsulfonate)

UNSPSC

12352005

Hazard Statement

H301-H351-H360

Target

Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/voriconazole-camphorsulfonate.html

Solubility

10 mM in DMSO

Smiles

O[C@@]([C@@H](C)C1=NC=NC=C1F)(CN2N=CN=C2)C(C(F)=C3)=CC=C3F.O=S(C[C@](C4=O)(CC[C@H]5C4)C5(C)C)(O)=O

Molecular Formula

C26H30F3N5O5S

Molecular Weight

581.61

Precautions

P264-P270-P280-P330-P405-P501

References & Citations

[1]Nickie D Greer. Voriconazole: the newest triazole antifungal agent.Proc (Bayl Univ Med Cent) . 2003 Apr;16 (2) :241-8.|[2]Lesley J Scott, et al. Voriconazole : a review of its use in the management of invasive fungal infections.Drugs. 2007;67 (2) :269-98.|[3]A M Sugar, et al. Efficacy of voriconazole in treatment of murine pulmonary blastomycosis.Antimicrob Agents Chemother. 2001 Feb;45 (2) :601-4.