Rel-Boc-Hyp-OMe
Rel-Boc-Hyp-OMe is the isomer of Boc-Hyp-OMe , and can be used as an experimental control. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Product Specifications
CAS Number
1145663-09-7
UNSPSC
12352005
Hazard Statement
H315, H319
Target
ADC Linker; PROTAC Linkers
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rel-boc-hyp-ome.html
Purity
99.74
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@H](C(OC)=O)C[C@@H](O)C1)OC(C)(C)C
Molecular Formula
C11H19NO5
Molecular Weight
245.27
Precautions
H315, H319
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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