Crizotinib (acetate)
Crizotinib (PF-02341066) acetate is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib acetate inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib acetate is also a ROS1 inhibitor. Crizotinib acetate has effective tumor growth inhibition[1][2][3].
Product Specifications
CAS Number
877399-53-6
Product Name Alternative
PF-02341066 (acetate)
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; c-Met/HGFR; ROS Kinase
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crizotinib-acetate.html
Solubility
10 mM in DMSO
Smiles
NC1=NC=C(C=C1O[C@H](C)C2=C(C=CC(F)=C2Cl)Cl)C3=CN(N=C3)C4CCNCC4.CC(O)=O
Molecular Formula
C23H26Cl2FN5O3
Molecular Weight
510.39
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Frequently Asked Questions
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