Palbociclib-d8
Palbociclib-d8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].
Product Specifications
CAS Number
1628752-83-9
Product Name Alternative
PD 0332991-d8
UNSPSC
12352005
Hazard Statement
H341, H361, H373, H411
Target
CDK; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.84
Solubility
DMSO : 1mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 8.33 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 80°C)
Smiles
O=C1N(C2=NC(NC3=NC=C(C=C3)N4C([2H])(C([2H])(NC([2H])(C4([2H])[2H])[2H])[2H])[2H])=NC=C2C(C)=C1C(C)=O)C5CCCC5
Molecular Formula
C24H21D8N7O2
Molecular Weight
455.58
Precautions
H341, H361, H373, H411
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
Frequently Asked Questions
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