Laropiprant (sodium)
Laropiprant sodium is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively[1][2][3].
Product Specifications
CAS Number
572874-50-1
Product Name Alternative
MK-0524 (sodium)
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/laropiprant-sodium.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC(F)=CC2=C1N(C3=C2CC[C@@H]3CC(O[Na])=O)CC4=CC=C(Cl)C=C4)(C)=O
Molecular Formula
C21H18ClFNNaO4S
Molecular Weight
457.88
References & Citations
[1]Labrecque P, et, al. Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. PLoS One. 2013 Jun 10;8 (6) :e65767.|[2]Sturino CF, et, al. Discovery of a potent and selective prostaglandin D2 receptor antagonist, [ (3R) -4- (4-chloro-benzyl) -7-fluoro-5- (methylsulfonyl) -1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524) . J Med Chem. 2007 Feb 22;50 (4) :794-806.|[3]Chang SW, et, al. The pharmacokinetics and disposition of MK-0524, a Prosglandin D2 Receptor 1 antagonist, in rats, dogs and monkeys. Xenobiotica. 2007 May;37 (5) :514-33.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
DP; TXA2/TP
Frequently Asked Questions
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