VHL Ligand intermediate-2

VHL Ligand intermediate-2 (compound 18c) is an intermediate for the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs[1].

Product Specifications

CAS Number

[2380273-24-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Ligands for E3 Ligase; SOS1

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sos1-ligand-intermediate-2.html

Purity

99.33

Solubility

10 mM in DMSO

Smiles

CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O

Molecular Formula

C28H40N4O5S

Molecular Weight

544.71

Precautions

H302, H315, H319

References & Citations

[1]Aurigene Discovery Technologies Limited, et al. Preparation of pyridazine derivatives as SMARCA2/4 degraders. World Intellectual Property Organization, WO2019207538 A1 2019-10-31.