KTX-582 intermediate-3

KTX-582 intermediate-3 is an intermediate in the synthesis of KTX-582 and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].

Product Specifications

CAS Number

2573304-30-8

UNSPSC

12352203

Target

Apoptosis

Type

ADC Related

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ktx-582-intermediate-3.html

Solubility

10 mM in DMSO

Smiles

CC(O)(C1=C(NC(C2=CC=CC(C(F)(F)F)=N2)=O)C=C3C=NN([C@@H]4CC[C@H](CC4)C(OCC)=O)C3=C1)C

Molecular Formula

C26H29F3N4O4

Molecular Weight

518.53

References & Citations

[1]Mainolfi, et al. Preparation of heterocycles as IRAK degraders and uses thereof. World Intellectual Property Organization, WO2020264499 A1. 2020-12-03.