Exatecan Intermediate 3

Exatecan Intermediate 3 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 3 can be used to synthesize Antibody-Drug Conjugates (ADCs) .

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/exatecan-intermediate-3.html

Purity

99.76

Solubility

10 mM in DMSO

Smiles

FC1=CC(N)=C2C(C(CCC2=C1C)NC(OCC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O)=O

Molecular Formula

C26H23FN2O3

Molecular Weight

430.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.