Dehydro Palonosetron (hydrochloride)
Dehydro Palonosetron hydrochloride (RS 42358-197 hydrochloride) is a 5-HT3 receptor antagonist. Dehydro Palonosetron hydrochloride has an antiemetic effect[1].
Product Specifications
CAS Number
[135729-55-4]
Product Name Alternative
RS 42358-197 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dehydro-palonosetron-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1N([C@@H]2CN3CCC2CC3)C=C4C5=C1C=CC=C5CCC4.[H]Cl
Molecular Formula
C19H23ClN2O
Molecular Weight
330.85
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Darmani NA, et al. Differential and additive suppressive effects of 5-HT3 (palonosetron) - and NK1 (netupitant) -receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation. Pharmacol Biochem Behav. 2015 Apr;131:104-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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