Dehydro Palonosetron

Dehydro Palonosetron (RS 42358-197) is a potent, seslective and orally active 5-HT3 receptor antagonist. Dehydro Palonosetron has no effect on the activities of 5-HT1 receptors, 5-HT2 receptors or 5-HT4 receptors[1].

Product Specifications

CAS Number

[135729-56-5]

Product Name Alternative

RS 42358-197

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dehydro-palonosetron.html

Solubility

10 mM in DMSO

Smiles

O=C1N([C@@H]2CN3CCC2CC3)C=C4C5=C1C=CC=C5CCC4

Molecular Formula

C19H22N2O

Molecular Weight

294.39

References & Citations

[1]R M Eglen, et al. RS 42358-197, a novel and potent 5-HT3 receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther. 1993 Aug;266 (2) :535-43.|[2]B Costall, et al. The effect of the 5-HT3 receptor antagonist, RS-42358-197, in animal models of anxiety. Eur J Pharmacol. 1993 Mar 30;234 (1) :91-9.