N-Boc-dolaproine-methyl
N-Boc-dolaproine-methyl is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580) . Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].
Product Specifications
CAS Number
[164456-57-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Microtubule/Tubulin; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-boc-dolaproine-methyl.html
Purity
98.23
Solubility
10 mM in DMSO
Smiles
O[C@H]([C@@H](C)C(OC)=O)[C@H]1N(C(OC(C)(C)C)=O)CCC1
Molecular Formula
C14H25NO5
Molecular Weight
287.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44 (5) : 937-940.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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