5-Amino-3H-imidazole-4-carboxamide (hydrochloride)

5-Amino-3H-imidazole-4-Carboxamide (AICA) hydrochloride is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular[1][2][3].

Product Specifications

CAS Number

[72-40-2]

Product Name Alternative

5-Aminoimidazole-4-carboxamide (hydrochloride) ; AICA (hydrochloride)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5-amino-3h-imidazole-4-carboxamide-hydrochloride.html

Purity

99.98

Solubility

10 mM in DMSO|H2O : ≥ 83 mg/mL

Smiles

O=C(C1=C(N)NC=N1)N.[H]Cl

Molecular Formula

C4H7ClN4O

Molecular Weight

162.58

Precautions

H302, H315, H319, H335

References & Citations

[1]YANG LIU. VARIABLE-TEMPERATURE 1 H-NMR AND AB INITIO STUDY OF 5-AMINO-IMIDAZOLE-4-CARBOXAMIDE (AICA) : COMPETING PATHS FOR AMIDE-H SCRAMBLING. DECEMBER 2008. |[2]Wojtaszewski JF, et al. Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA) -riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle. Diabetes. 2002 Feb;51 (2) :284-92. |[3]Sheldrick W S, et al. The structures of two tricyclic phosphoranes displaying facial placement of the fused bicyclic system[J]. Acta Crystallographica Section B: Structural Crystallography and Crystal Chemistry, 1980, 36 (10) : 2316-2323.