Taltobulin intermediate-8

Taltobulin intermediate-8 is an intermediate in the synthesis of Taltobulin (HY-15584) . Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

Product Specifications

CAS Number

[676487-38-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/taltobulin-intermediate-8.html

Purity

98.08

Solubility

10 mM in DMSO

Smiles

OC([C@H](N(C(OC(C)(C)C)=O)C)C(C)(C)C1=CC=CC=C1)=O

Molecular Formula

C17H25NO4

Molecular Weight

307.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63 (8) :1838-45.