NH2-C4-NH-Boc

NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Product Specifications

CAS Number

[68076-36-8]

UNSPSC

12352211

Hazard Statement

H314, H318

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nh2-c4-nh-boc.html

Purity

99.98

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

NCCCCNC(OC(C)(C)C)=O

Molecular Formula

C9H20N2O2

Molecular Weight

188.27

Precautions

H314, H318

References & Citations

[1]Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28 (1) :115181.