7α,25-Dihydroxycholesterol intermediate-1
7α,25-Dihydroxycholesterol intermediate-1 is an intermediate in the synthesis of 7α,25-Dihydroxycholesterol. 7α,25-Dihydroxycholesterol (7α,25-OHC) can be used as a ligand to target the orphan GPCR receptor EBI2 (GPR183). body, used to synthesize the corresponding PROTEACs[1].
Product Specifications
CAS Number
1326612-12-7
UNSPSC
12352005
Target
EBI2/GPR183; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
GPCR/G Protein; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/7α-25-dihydroxycholesterol-intermediate-1.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CCCC(C)(C)OC(C4=CC=CC=C4)=O)C)([H])[C@@]5(C(C[C@H](CC5)OC(C6=CC=CC=C6)=O)=C1)C
Molecular Formula
C41H54O5
Molecular Weight
626.86
References & Citations
[1]Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475 (7357) :519-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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