Duocarmycin SA intermediate-2

Product Specifications

CAS Number

[2209030-98-6]

UNSPSC Description

Duocarmycin SA intermediate-2 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-2 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor suppressor cytotoxicity with proton irradiation[1].

Target Antigen

Antibiotic

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

cancer

Assay Protocol

https://www.medchemexpress.com/duocarmycin-sa-intermediate-2.html

Solubility

10 mM in DMSO

Smiles

C[Si](C(C)(C)C)(C)OCC1=CN(S(C2=CC=C(C)C=C2)(=O)=O)C3=C1C=CC(OCC4=CC=CC=C4)=C3

Molecular Weight

521.74

References & Citations

[1]MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. [Content Brief]