Tubulysin A intermediate-1
Tubulysin A intermediate-1 is an intermediate in the synthesis of the cytotoxic peptide Tubulysin A (HY-15995) . Tubulysin A (TubA) is an antibiotic, anti-microtubule toxins, and apoptosis inducer isolated from myxobacteria. Tubulysin A has anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative activities. Tubulysin A arrests cells in the G2/M phase, effectively inhibits tubulin polymerization, and induces depolymerization of detached microtubules. Tubulysin A acts as an ADC cytotoxin (ADC Cytotoxin) to synthesize ADC[1].
Product Specifications
UNSPSC
12352203
Target
Bacterial
Type
ADC Related
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulysin-a-intermediate-1.html
Solubility
10 mM in DMSO
Smiles
O[C@@H](C1=NC(C(OCC)=O)=CS1)C[C@H](C(C)C)N(COC(CC(C)C)=O)C([C@@]([C@@H](C)CC)([H])NC([C@@H](CCCC2)N2C)=O)=O
Molecular Formula
C31H52N4O7S
Molecular Weight
624.83
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
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