Tubulysin A intermediate-1
Product Specifications
UNSPSC Description
Tubulysin A intermediate-1 is an intermediate in the synthesis of the cytotoxic peptide Tubulysin A (HY-15995). Tubulysin A (TubA) is an antibiotic, anti-microtubule toxins, and apoptosis inducer isolated from myxobacteria. Tubulysin A has anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative activities. Tubulysin A arrests cells in the G2/M phase, effectively inhibits tubulin polymerization, and induces depolymerization of detached microtubules. Tubulysin A acts as an ADC cytotoxin (ADC Cytotoxin) to synthesize ADC[1].
Target Antigen
Bacterial
Type
ADC Related
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulysin-a-intermediate-1.html
Solubility
10 mM in DMSO
Smiles
O[C@@H](C1=NC(C(OCC)=O)=CS1)C[C@H](C(C)C)N(COC(CC(C)C)=O)C([C@@]([C@@H](C)CC)([H])NC([C@@H](CCCC2)N2C)=O)=O
Molecular Weight
624.83
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-400684/Tubulysin-A-intermediate-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-400684/
Clinical Information
No Development Reported
Curated Selection
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