Acetohexamide

Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12 (S) -HETE. Acetohexamide can potentiate hypoglycaemic action[1][2][3][4].

Product Specifications

CAS Number

[968-81-0]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Acetohexamide.html

Purity

99.67

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(C(C)=O)C=C1)(NC(NC2CCCCC2)=O)=O

Molecular Formula

C15H20N2O4S

Molecular Weight

324.40

Precautions

H302, H312, H332

References & Citations

[1]White JA, et al. Nonhypoglycemic drug reactions of agents used to treat diabetes. Endocrinol Metab Clin North Am. 2000 Dec;29 (4) :803-11.|[2]Kishimoto, M., et al., (1994) . Carbonyl reductase activity for acetohexamide in human erythrocytes. Drug metabolism and disposition: the biological fate of chemicals, 22 (3), 367–370.|[3]Kretschy, N., et al., (2013) . In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. British journal of cancer, 108 (3), 570–578.|[4]Imamura, Y., et al., (1990) . Mechanism of pharmacodynamic and pharmacokinetic interactions between acetohexamide and phenylbutazone in rabbits. Pharmacology & toxicology, 67 (5), 415–419.