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4-Amino-2-chloropyrimidine

4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (Ki = 0.18 μM) and BChE (Ki = 1.324 μM) . 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC50 = 0.037 μM, Ki = 0.047 μM) in vitro[1][2].

Product Specifications

CAS Number

[7461-50-9]

UNSPSC

12352200

Hazard Statement

H302, H319

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/4-amino-2-chloropyrimidine.html

Purity

99.90

Solubility

DMSO : ≥ 100 mg/mL

Smiles

ClC1=NC=CC(N)=N1

Molecular Formula

C4H4ClN3

Molecular Weight

129.55

Precautions

H302, H319

References & Citations

[1]Duran H. E. (2023) . Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry, 70 (1), 68–82.|[2]O'Hare, T., et al., (2004) . Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood, 104 (8), 2532–2539.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-30139/4-Amino-2-chloropyrimidine-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-30139/4-Amino-2-chloropyrimidine-SDS-MedChemExpress.pdf

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Curated Selection

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